NQO2 was reported to participate in numerous human diseases, including cancer[32] and neurodegenerative diseases.[33] Previous study showed that loss of NQO2 displayed slower proliferation and G1 phase cell accumulation in prostate cancer.[34] The regulation of NQO2 on ROS led us to postulate its oncogenic role in NSCLC. The gene discussed is NQO2; the disease is cancer.