HSPA5 and non-small cell lung carcinoma: To determine whether ROS‐ER stress signaling is essential for the anticancer effect of curcumol/TRAIL in NSCLC, we introduced ROS scavenger N‐acetyl‐cysteine (NAC) to reduce the ROS levels enhanced by curcumol (Figure 5A), and found that curcumol‐induced ER stress could be suppressed by NAC, as indicated by the expression of HSP90, BIP, and PDI (Figure 5B).