Curcumol exhibits synergistic lethal effects with TRAIL on cancer cell by directly targeting quinone oxidoreductase 2 (NQO2) to induce reactive oxygen species, triggering ER stress‐C/EBP homologous protein (CHOP)‐death receptor 5 (DR5) signaling to combat TRAIL‐resistant cancer. This evidence concerns the gene TNFSF10 and cancer.