Recent studies have shown that DR5 upregulation by chemotherapy agents could overcome TRAIL resistance,[24, 35] and ER stress can induce the increase of DR5 expression in a wide spectrum of human cancers via transactivation of the transcription factor CHOP.[36] CHOP binds to 5’ untranslated region of DR5 promoter to initiate DR5 expression in response to ER stress inducers. The gene discussed is DDIT3; the disease is cancer.