EPCAM and cancer: Based on the higher adhesion force of MCF‐7 cells over PBMCs, the reversed centrifugation method was used to improve the capture purity (Figure S19, Supporting Information), but it was not further used for the precise CTC counting, due to the loss of ≈13% captured cancer cells after centrifugation with 1238 × g. Notably, the nanocage of the EChry pollen could capture a broad spectrum of cancer cell types, including A431 (epithelial cell adhesion molecules+, EpCAM+), Hela (EpCAM−), A549 (EpCAM−), and HepG2 (EpCAM−), from the PBMC suspension, giving a capture yield as high as 93% (Figure 3d).