TGM2 and glioblastoma: demonstrated that the subventricular zone of the brain can modulate GBM microenvironment and take part in MES transformation through C/EBP‐β signaling.[52] Another study reported that transglutaminase 2 (TGM2) can act as a mediator of mesenchymal transformation in perinecrotic regions of GBM by inducing C/EBP‐β expression through GADD153 (a transcriptional inhibitor of C/EBPβ signaling) degradation.[53] Accumulating evidence demonstrated the role of STAT3 in PMT.