External stimuli such as growth factors, cytokines, and hypoxic environment induce a vast array of signaling pathways and associated transcription factors (SNAI1, SLUG, ZEB, and TWIST) leading to EMT transition.[21] The same molecular events are also involved in mesenchymal transition in GBM leading to increased tumor aggressiveness and acquired drug resistance. The gene discussed is ZEB1; the disease is neoplasm.