Later, a combined genetic analysis collected from three different sources by The Cancer Genomic Atlas (TCGA) identified 840 genes and classified GBM into four different subtypes: pro‐neural, neural, classical, and mesenchymal.[12] The classical subtypes are characterized by lack of TP53 mutation, EGFR amplification associated with expression of retinoblastoma (RB), sonic hedgehog, and Notch signaling pathway. This evidence concerns the gene EGFR and glioblastoma.