ZEB1 and neoplasm: Mechanistically, miR‐205 targets 3′‐UTR region of ZEB1 and induces the expression of E‐cadherin, while suppressing N‐cadherin and vimentin.[75] A study using transcription data from TCGA showed that miR‐504 downregulation is associated with GBM MES subtype and poor survival, while overexpression of this miRNA suppresses mesenchymal transition and tumor aggressiveness.[47] miR‐504 targets the 3′‐UTR region of FZD7 and modulate the activity of Wnt‐β‐catenin signaling.