The protein target is a member of the lipid kinases family, which regulates signaling pathways important for cell proliferation, adhesion, survival, and motility.[38] The PIK3CA gene, coding for the p110α subunit, is frequently mutated in cancer [39] and represents an attractive target for the development of small molecule inhibitors, some of which are currently in preclinical evaluation and some are approved therapeutics.[40]. This evidence concerns the gene PIK3CA and cancer.