MYSM1 and glomerulosclerosis: Cells undergoing senescence display functional changes leading to the aging process, which is linked to many pathological changes in the kidneys, such as fibrosis, glomerular sclerosis, and nuclear damage.[41, 42] In 6‐month‐old Mysm1−/− mice, glomerular sclerosis, tissue destruction, inflammatory infiltration, pyknosis, and renal bleeding were observed in the kidney (Figure S6A, Supporting Information).