CD40LG and polycystic ovary syndrome: Preliminary investigations done in PCOS women who were involved in various observational and randomized controlled trials demonstrated high serum homocysteine levels in most of the studies along with other cardiovascular disease serum biomarkers such as high sensitivity C-reactive protein, plasma soluble CD40 ligand (sCD40L), and asymmetric dimethylarginine (ADMA) [12,13].