On the contrary, abundant literature suggested that YAP1 is a tumor suppressor gene and nuclear expression is reduced in different cancers, such as breast cancer (Matallanas et al., 2007; Yu et al., 2013; Yuan et al., 2008), head and neck cancers (Ehsanian et al., 2010), hematological cancers (Cottini et al., 2014), and CRC (Levy et al., 2007). This evidence concerns the gene YAP1 and neoplasm.