Prior studies had illustrated the expression of YAP1 in a various cancers including CRC (Cottini et al., 2014; Ehsanian et al., 2010; Kang et al., 2011; Kim, Jung & Koo, 2014; Levy et al., 2007; Liu et al., 2013; Matallanas et al., 2007; Wang et al., 2013a; Wang et al., 2010; Xu et al., 2009; Yu et al., 2013; Yuan et al., 2008), but the association between subcellular localization of YAP1 and aggressiveness of CRC has been neglected. Here, YAP1 is linked to colorectal carcinoma.