Three co-upregulated genes were identified: GLRX, RNF13, and ABCA1. Furthermore, the expressions of these 3 genes in vulnerable atherosclerosis plaques were explored, and all of them were increasingly expressed in unstable or ruptured plaques compared to their expression levels in stable plaques, although some of the increased levels were not statistically significant. The gene discussed is RNF13; the disease is atherosclerosis.