Since the cases of rare homozygous genotype C/C rs78378222 detection in normal tissue have not been described previously, and DNA extraction was carried out from paraffin blocks contained not less than 50% of tumor tissue, the gained results demonstrated a heterozygosity loss in the TP53 of the rs78378222 in tumor tissue of patients DLBCL. This evidence concerns the gene TP53 and neoplasm.