LPP1 and LPP3 play anti-cancer roles and restoration of expression in tumour cells results in suppression of tumour growth, migration and metastasis in mouse models (Tang et al., 2014; Tang, McMullen & Brindley, 2019; Tanyi et al., 2003a; Tanyi et al., 2003b). This evidence concerns the gene PLPP3 and neoplasm.