ASPG and acute lymphoblastic leukemia: In this work, we develop a strategy based on bioinformatics tools to analyze and select ASNases from Streptomyces for ALL treatment, taking advantage of its phylogenetic distance from E. coli, looking for those candidates that meet the two fundamental criteria: asparaginases with high affinity for asparagine (using active site prediction tools and molecular docking), and that have lower immunogenicity (using antigenicity and protein structure prediction tools).