As shown in Fig. 10, the changes of IVL, FLG, SPRR1B, DSG3, KRT5, DSG1, KRT16, PKP1, KRT14 and DSC3 in melanoma patients were associated with shortened overall survival, which suggested that these hub genes expression differences may be related to the progression and prognosis of cutaneous melanoma, thus can be used for predicting the deterioration and improvement of CM. The gene discussed is SPRR1B; the disease is melanoma.