Most hub genes, such as LOR, IVL, FLG, DSG3, TGM1, KRT16, SPRR1A, KRT14, DSP and CSTA, showed no difference in the expression of PM and N, but significantly decreased in MM and PM, suggesting that these genes might be potential predictors of CM metastasis. The gene discussed is KRT16; the disease is Miyoshi myopathy.