However, another study showed that increased APLNR expression was significantly correlated with decreased median overall survival by 14.7 months in patients with high-grade serous ovarian cancer, and APLNR expression was both necessary and sufficient to increase prometastatic phenotypes of ovarian cancer cells including the proliferation, cell adhesion, migration and invasion in vitro (Neelakantan et al., 2019). Here, APLNR is linked to ovarian serous adenocarcinoma.