Tumor-derived CXCL5 can promote human CRC metastasis by activating ERK/Elk-1/Snail and AKT/GSK3β/β-catenin pathway, accelerate osteosarcoma growth and can serve as a biomarker for non-small cell carcinoma, etc. (Roca et al., 2018; Wu et al., 2017; Zhao et al., 2017). Here, AKT1 is linked to osteosarcoma.