The relationship between TC and the nine target genes (INS, BCL2, PTEN, PPARG, PDCD1, CXCL12, EP300, TGFBR2, and CHI3L1) were supported by previous studies (see TC_Obesity →ShortestPath), which supports the potential association between the five obesity-regulated genes (FABP4, CFD, GHR, TNFRSF11B, and LTF) and TC. Here, PTEN is linked to obesity due to melanocortin 4 receptor deficiency.