BAP1 and cancer: Even though the penetrance of having a BAP1 germline variant has been shown incomplete and the type of BAP1-related cancers has been observed to vary among different family members42, our findings contribute to providing functional support for resolution of BAP1 variants with uncertain significance and facilitating clinical interpretation by clinicians so that appropriate prognosis, therapeutic intervention strategies and care may be delivered to patients with BAP1 tumour predisposition syndrome.