Even if the composition of PM is influenced by several factors, including geographical distribution, PM samples from Po valley and Wuhan city, the first and most severely affected areas globally, during the early months of COVID-19 outbreak, showed the same ability to induce the angiotensin II-dependent proinflammatory cytokine production in cell models (Colacci et al., 2014; Vaccari et al., 2015; Xu et al., 2016). This evidence concerns the gene AGT and COVID-19.