THBS1 and Hyperglycemia: These effects are likely to be mediated at least in part, by the AhR, whose role in hyperglycemia and vascular complications in diabetic patients, has been described and ascribed to its ability to form a complex with several transcription factors activated by glucose, including thrombospondin 1, a protein implicated in the development of vascular complications in diabetic patients (Dabir et al., 2008).