Astrocyte-derived NF-κB activation was neuroprotective in presymptomatic stage by delaying disease onset, but it facilitated the inflammatory process by the activation of microglial, which induced motor neuron death in ALS models (Frakes et al., 2014; Ouali Alami et al., 2018). The gene discussed is NFKB1; the disease is amyotrophic lateral sclerosis.