RNF5 is involved in the control of breast cancer progression and in survival of breast cancer patients (Bromberg et al., 2007). Ubiquitin ligase RNF5 serves an important role in the development of human glioma. RNF5 was significantly associated with diagnosis and prognosis of Hepatocellular carcinoma (Zhu et al., 2016; Gao et al., 2019). The gene discussed is RNF5; the disease is central nervous system cancer.