CACNA2D3 was downregulated in esophageal squamous cell carcinoma, nasopharyngeal carcinomas and gliomas (Li et al., 2013; Wong et al., 2013; Jin et al., 2017) and has an antitumor role in endometrial cancer (Kong et al., 2020). The gene discussed is CACNA2D3; the disease is esophageal squamous cell carcinoma.