Accumulating evidence indicates that RAD50 is a breast cancer susceptibility gene associated with genomic instability (Heikkinen et al., 2003, 2006; Hsu et al., 2007; Damiola et al., 2014; Kleibl and Kristensen, 2016; Kim et al., 2017; Bian et al., 2019). This evidence concerns the gene RAD50 and breast cancer.