Although we demonstrate that the decrease in blood GPR183 in TB + T2D patients is likely due, in part, to a decreased frequency of non-classical monocytes expressing GPR183, we cannot rule out that reduced GPR183 expression in whole blood is partially attributable to neutrophils and eosinophils as preferential loss of neutrophils and eosinophils occurs upon PBMC isolation. The gene discussed is GPR183; the disease is tuberculosis.