Thus, based on the foregoing reference that hyperthermia can either activate or enhance the immune response and upregulate PD-L1 in several kinds of tumors, we propose that treatment with hyperthermia creates a type I like tumor immune microenvironment with tumor infiltrating lymphocytes (TILs) and upregulates PD-L1 to work in complement with ICIs for cancer treatment (Figure 1). The gene discussed is CD274; the disease is neoplasm.