Based on the immune status of TME, tumors can be classified as “cold” and “hot” in which “cold” tumors often have a low response rate to anti-PD-1/PD-L1 mAb due to reduced tumor mutation, less T-cell infiltration, less PD-L1 expression and enrichment in immunosuppressive cells (3). The gene discussed is CD274; the disease is neoplasm.