Studies have found that the combination of ICIs (CTLA-4, PD-L1, IDO) and nanoparticle-mediated hyperthermia can promote antigen capture, enhance ICD effect, inhibit Treg cells’ function, promote M1 macrophages’ differentiation, recruit several folds of tumor-infiltrating lymphocytes, and achieve lasting memory for the inhibition of tumor growth in primary and distant sites (106–114). This evidence concerns the gene IDO1 and neoplasm.