The MS lesion exhibits marked diversity: Park and colleagues used imaging mass cytometry to examine the heterogeneity of CNS-associated macrophages and found that their diversity could be stratified based on their relative location within the MS lesion with enriched lysosomal LAMP1 or receptor tyrosine kinase MERTK expression on myeloid cells located at the lesion rim (115, 116). Here, LAMP1 is linked to myeloid sarcoma.