This is concordant with all of these antigens being ranked as the top 20 most immunodominant and immunogenic in vivo expressed TB proteins (IVE-TB) in Mtb-exposed individuals (21), that they (or their homologous partners) show 100% CD4 T cell reactivity in individuals with LTBI (37), and that all of them are described as vaccine targets (34, 35, 49). The gene discussed is CD4; the disease is tuberculosis.