In recent years, the development of specific molecularly targeted agents has primarily changed the therapeutic landscape for advanced NSCLC patients, including epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs)-, anaplastic lymphoma kinase (ALK)-, and BRAF-inhibitors (Rosell and Karachaliou, 2016). This evidence concerns the gene EGFR and non-small cell lung carcinoma.