miR-17 inhibits HGF/ERBB3-NF-kB positive loop suppressing post-operative metastasis of HCC (130); miR-17 downregulated netrin 4 promoting migration and invasion of breast cancer cells (131); miR-17 targets SIK1 leading to the proliferation and migration of human colorectal cancer cells (132); overexpression of miR-17 in human fibroblasts co-cultured with colon cancer cells remarkably reduced invasion of cancer cells (133); miR-17 targets ETV1 in triple negative breast cancer suppressing proliferation, migration, and tumor metastasis (134). The gene discussed is SIK1; the disease is cancer.