Overexpression of ITSN1 leads to anchorage-independent growth and tumorigenesis in neuroblastoma (97, 98) and proliferation of glioblastoma cells through Raf/MEK/ERK pathway activation (99), demonstrating an essential role of ITSN1 in the development of malignancy and tumor progression. Here, ITSN1 is linked to glioblastoma.