MMP2 and central nervous system cancer: Interestingly, miR-10b regulated the orchestra of transcription factors such as HOXD10, PAX6, TP53, and NOTCH1, repressing invasion-related genes RHOC, PLAUR, MMP2, and CTNNB1, and decreasing the invasive potential of mesenchymal type glioma cell line U87-2M1 (182).