Overexpressed miR-27 promoted multiple myeloma cell proliferation, cell migration, and invasion (147); miR-27b targets Sp1 leading to the inhibition of growth and invasion of NSCLC cells (148); miR-27 is overexpressed in invasive adenocarcinomas with the linear increase of microRNA level according to the stage (149); miR-27a targets tumor suppressor MCPH1 in renal cancer (150); upregulation of miR-27a promoted migration, invasion, and angiogenesis of thyroid cancer cells (151). The gene discussed is SP1; the disease is thyroid gland carcinoma.