In lung adenocarcinoma metastasis cells, miR-133 acts as a tumor suppressor targeting FLOT2 via Akt signaling pathway (159); in gastric cancer, miR-133 downregulates CDC42 expression, and PAK activation inhibiting cancer cell proliferation and migration (160); in U87 glioma cell lines, miR-133 targets FOXC1 suppressing tumor growth, and invasion (161). The gene discussed is FLOT2; the disease is central nervous system cancer.