Decrease of HIF1α and HIF2α expression levels leading to the reduction of cell migration and invasion (122); miR-199 targets Snail resulting in inhibition of EMT and invasion of hepatoma cells (145); miR-199 downregulated RGS17 resulting in suppression of proliferation, migration, and invasion of hepatocellular carcinoma cells (146). This evidence concerns the gene HIF1A and hepatocellular carcinoma.