MiR-17 is overexpressed in peripheral mononuclear blood cells (PMBC) from PD patients (127), downregulation of miR-17 led to paraquat-induced dopaminergic degradation (128); miR-17 responses to formaldehyde treatment and modulates EPHA4, GNPDA2 and TXNIP expression in the brains of MGMT–/– mice involved in amyloid deposition, neurotransmission, and response to oxidative stress (129). The gene discussed is MGMT; the disease is Parkinson disease.