Mutations in the dystrophin gene in Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD), or sarcoglycan genes in limb-girdle muscular dystrophies (LGMDs) lead to muscle sarcolemma destabilization and fragility (He et al., 2012). The gene discussed is DMD; the disease is Becker muscular dystrophy.