In order to investigate the impact of RNase A on angiogenesis, we used a murine hindlimb model, in which FAL results in arteriogenesis in the upper leg (adductor muscle) and due to provoked ischemia in angiogenesis in the lower leg (gastrocnemius muscle; Figure 1; Lasch et al., 2019a). The gene discussed is RNASE1; the disease is ischemia.