When hypertensive stimuli persist, these effector memory T-cells infiltrate into the vasculature and the kidney and release cytokines like interferon gamma (INF-γ), interleukin-17 (IL-17), and tumor necrosis factor alpha (TNF-α), which aggravate hypertension (Madhur et al., 2010). The gene discussed is TNF; the disease is hypertensive disorder.