BIN1 and Alzheimer disease: A three-stage analysis of 8,371 AD cases identified that SNP rs744373 in BIN1 attained genome-wide statistical significance (OR = 1.13; 95% CI:1.06–1.21; P = 1.6 × 10–11), suggesting that the BIN1 gene is a risk factor for AD (Seshadri et al., 2010).