SIGMAR1 and nervous system disorder: According to the modern concept (Kourrich et al., 2012), in the process of neurological disorders development, SIGMA1R is translocated from MERCs to other parts of the cell, as a result of which SIGMA1R binds to various ion channels, receptors, or kinases (NMDA, Src, D1R, PLC, DA transporter) and modulates their activity.