RHOT1 and Parkinson disease: Indeed, PD-related mutations in Miro1 (Mitochondrial Rho GTPase 1), a MERCs-localized protein (Modi et al., 2019), lead to the decreased mitochondrial transport in neurons, increased ER-mitochondrial tethering, and the adverse effect toward regulation of mitophagy and Ca2+ homeostasis (Berenguer-Escuder et al., 2020).