APP and Neurodegeneration: We have exploited XPCT to study the APP/PS1dE9 mouse model of AD (Balducci and Forloni, 2011), a progressive neurodegenerative disorder associated with aberrant production of Aβ depositing in the brain as extracellular plaques, especially in the cortical and the hippocampal areas (Huang and Mucke, 2012).