We have exploited XPCT to study the APP/PS1dE9 mouse model of AD (Balducci and Forloni, 2011), a progressive neurodegenerative disorder associated with aberrant production of Aβ depositing in the brain as extracellular plaques, especially in the cortical and the hippocampal areas (Huang and Mucke, 2012). The gene discussed is APP; the disease is Alzheimer disease.