As a gastrointestinal hormone, it mainly regulates intestinal epithelial cell growth and functions that are crucial for digestion and absorption of nutrients.2 Similar to GLP-1, GLP-2 is rapidly inactivated by dipeptidyl peptidase 4 in vivo.3 Clinically, GLP-2 analogue, teduglutide, is used to treat short bowel syndrome and Crohn’s disease. This evidence concerns the gene GLP1R and Crohn disease.