Bone marrow NK cells from AML patients had higher expression levels of interferon-induced genes (IFI44L, IFI6, IFIT3, and IFI44), HLA molecule-encoding genes (HLA-DPB1, HLA-DPA1, HLA-DRB5, and HLA-DRB1), ZEB2, and KLF2, which encode transcription factors controlling NK cell maturation36 and survival,53 respectively. The gene discussed is HLA-DRB5; the disease is acute myeloid leukemia.