IL15 and acute myeloid leukemia: Consistent with the well-known impairment of NK cell function during AML,24,25,27 NK cells isolated from healthy individuals had a transcriptomic profile enriched in genes involved in cell cytotoxicity, the FcγR receptor signaling pathway, exocytosis, and the response to IL-12 and IL-15 signaling pathways, indicating a more activated NK cell phenotype for these cells than for those isolated from AML patients.