In our association analyses between cg19693031 methylation locus and gene expression we could see that rather than affecting the expression of its “own” gene TXNIP the locus shows association with the expression of lipid associated genes SREBF1 and ABCG1. Notably, in our analyses, cg19693031 was the only successfully replicated methylation site binding all of the different components together with MetS. The gene discussed is TXNIP; the disease is metabolic syndrome.