To unravel the molecular mechanism underlying the development of obesity-dependent liver tumors in Nod2−/− mice in a unbiased manner, we performed RNAseq using total RNA from the livers of male WT and Nod2−/− mice treated with DMBA and maintained on HFD for 31 weeks. Here, NOD2 is linked to obesity due to melanocortin 4 receptor deficiency.