Underscoring the rationality of our selected input attributes, for example, high NIHSS score, and Af have been suggested to increase the risk of post-thrombolysis hemorrhagic transformation and poor AIS outcome19,20; in fact, Whiteley WN, et al. in a systematic review and meta-analysis of 55 studies showed that a higher stroke severity with an odds ratio of ~ 1.1 per NIHSS point is associated with post-tPA sICH, and that the odds double in the presence of Af-related cardioembolic stroke subtype18. This evidence concerns the gene PLAT and Stroke.