Our result demonstrated that high baseline diastolic BP, lower level of LDL, history of hyperlipidemia, Af, and heart disease were associated with sICH, while aging, lower dose of tPA, lower baseline GCS score, higher NIHSS score, history of DM and ischemic heart disease, were predictors of the post-tPA 3-month mortality. The gene discussed is PLAT; the disease is coronary artery disorder.