PTEN and neoplasm: Ectopic expression of PTEN significantly diminished tumour cell invasion as well as Akt phosphorylation and EMT marker proteins induced by CDX2 knockdown (Supplementary Figs. 10c, e and 11c, d); conversely, knockdown of PTEN recovered the tumour-suppressive effect of CDX2 overexpression (Supplementary Figs. 10d, f and 11e, f).