CDX2 and neoplasm: PTEN acts as negative regulator of PI3K-mediated AKT activation in cell homoeostasis.59 Inactivation of PTEN has been reported to participate in EMT acquisition during the process of tumour metastasis.60 Emerging evidence indicated that PTEN can be regulated at the transcriptional level as well as by numerous post-transcriptional modifications.59 We observed that CDX2 regulated PTEN expression at both mRNA and protein levels.