CDX2 and colorectal carcinoma: The PI3K/Akt pathway impedes the activity of GSK-3β, leading to the stabilisation and nuclear translocation of β-catenin to promote cell proliferation, differentiation and EMT.20 Here, we reported that CDX2 knockdown promoted the stabilisation and nuclear translocation of β-catenin in CRC, while ectopic expression of CDX2 had the reserved alterations.