The direct target of PTEN by EBV-miR-BART7-3p exhibits a similar alteration in nasopharyngeal carcinoma.14 However, Elumalai et al. reported that the level of total β-catenin was reduced in PTEN-inactivated lung cancer cells, despite the accumulation of β-catenin in cell nucleus.60 These studies unanimously concluded that PTEN inactivation in tumour induces the nuclear accumulation of β-catenin, although the total β-catenin level might exhibit the inconsistent alteration. Here, PTEN is linked to lung cancer.