As previously reported, Slug and ZEB1 might be two of the target genes of β-catenin in CRC.22 The depletion of β-catenin reduced Slug, ZEB1 and vimentin, as well as elevated E-cadherin and ZO-1 (Supplementary Fig. 7d and 9d). This evidence concerns the gene TJP1 and colorectal carcinoma.