CD8A and neoplasm: Once in the space of Dissé, tumour cells are able to recruit myeloid-derived suppressor cells, which can then modulate the tumour cell immune microenvironment by, for example, suppressing CD8+ T cells, thereby promoting colonisation of the liver with cancer cells.72 However, the formation of micrometastases in the space of Dissé is limited by the availability of a vascular network.