Meanwhile, miR-199b-5p restoration or DDR1 silencing can induce a transition from a mesenchymal-like toward a more cobblestone-like epithelial phenotype (Fig. 5a), as supported by the E-cadherin overexpression and the downregulation of vimentin and fibronectin expression in PCa cells and xenograft tumours (Figs. 4a, b, 5b, c). The gene discussed is CDH1; the disease is posterior cortical atrophy.