KIT and plasma cell myeloma: Routine tests of peripheral blood revealed a significant decrease in Hgb levels in all mice injected with MM-5TGM1 myeloma cells compared those in tumour-free control mice (119 ± 5 vs. 142 ± 5 g/L, n = 10; Supplementary Figure 3C. In this myeloma mouse model, we also did not find significant variation in either the proportion or absolute number of haematopoietic stem cells (LSK: Lin−c-Kit+Sca-1+) (0.042% ± 0.006% vs. 0.043% ± 0.005%; Fig. 2E,F).