Also, GATA3, ERRB3, RUNX1, BAP1, and TBX3 were the top five hub genes in the blue module, whereas in the turquoise module was RB1, ZFP36L1, SMAD4, SF3B1, and CDKN1B. RUNX1, GATA3, and TBX3 were the top three significant and module memberships for tumor stages in the blue module. The gene discussed is RB1; the disease is neoplasm.