CD274 and neuroblastoma: To further examine the clinical significance of THBD expression in NB, we performed immunohistochemistry (IHC) analysis on a cohort of 104 NB samples (which included the Nanostring-NB samples), previously characterized for the density of T cells and expression of HLA class I and the immune-checkpoint molecules PD-1, PD-L1, and LAG319,29.