We evaluated the patient survival status after combining the expression of THBD- and NCR1-associated genes and found that high expression of both gene clusters was associated with increased survival in the SEQC-NB dataset, employed as the training set for the signature discovery (log-rank P values: 3.24 × 10−10 and 1.55 × 10−11 for overall survival of THBD- and NCR1-associated genes, respectively, and log-rank P values: 4.62 × 10−6 and 5.57 × 10−5 for event-free survival of THBD- and NCR1-associated genes, respectively) (Fig. 6f and Supplementary Fig. 13a). Here, THBD is linked to neuroblastoma.