CFTR and cystic fibrosis: We observed three sources of evidence in our data linking EGR1 to CF or CFTR, namely: (1) up-regulation of the EGR1 transcript in both the CF bronchial and nasal signatures (see Fig. 3A); (2) up-regulation of its transcriptional targets via ChIP-X Enrichment Analysis of the CF-Meta signature (see Fig. 3A and Table 1); and (3) over-representation of its transcriptional targets in the CFG genes (see Additional File 4).