HES1 and hepatocellular carcinoma: To further examine whether NCOA3 promoted HCC growth via the TERT signaling pathway, we examined the expression of the Wnt target genes in NCOA3 knockdown Hep3B cells and found that knockdown of NCOA3 decreased the expression of the Wnt targets MYC, TCF-1, and CCND1, but had no effect on the expression of the Notch target genes HES1, HES6, HEY1, and NRARP (Fig. 4F).