CAT and Alzheimer disease: Figure 8D summarizes the expression and distribution of CAT in neurons and astrocytes in all of the analyzed conditions (ctrl vs ctrl, p = 0.0044; AD vs AD, p < 0.0001; NDAN vs NDAN, p < 0.0001). Somewhat surprisingly, a prominent nuclear rather than the canonical cytosolic localization of the scavenger enzyme was detected in NDAN patients, as shown in Figure 8, B and C.