SOD2 and Alzheimer disease: Noteworthy, and consistent with the dramatic oxidative damage, we found a significant decrease of total SOD2 levels in AD versus control brains, which are especially sharp in neurons, thus supporting the idea that altered expression of this mitochondrial enzyme is crucial in the progression of AD pathology (Cimini et al., 2009; Massaad et al., 2009; Fanelli et al., 2013; Flynn and Melov, 2013; Hroudová et al., 2014; Porcellotti et al., 2015; Majd and Power, 2018; Swerdlow, 2018; Perez Ortiz and Swerdlow, 2019).