As PGC1α regulates mitochondrial and peroxisomal biogenesis (Austin and St-Pierre, 2012), a correlation between the oxidative stress observed in AD frontal cortices and dysfunctions of these organelles, likely because of PGC1α downregulation, could be hypothesized (Demarquoy and Le Borgne, 2015; Sweeney and Song, 2016; Wanders et al., 2016). The gene discussed is PPARGC1A; the disease is Alzheimer disease.