SOD2 and Alzheimer disease: Particularly, given the well established role of mitochondrial dysfunction as one of the central cytopathologies of AD (Reddy, 2014; Sweeney and Song, 2016; Swerdlow, 2018; Perez Ortiz and Swerdlow, 2019), we analyzed the expression of the mitochondrial O2–.-scavenging enzyme SOD2 in frontal cortices from AD, NDAN, and normally aged individuals.