INS and diabetes mellitus: Furthermore, transgenic mice with tamoxifen-inducible overexpression of an active nuclear-restricted form of human Myc under the insulin promoter (pIns-c-MycERTAM) in adult β-cells also display both rapid onset of β-cell proliferation and apoptosis leading to diabetes (29), confirming the previous results observed in transgenic mice with sustained Myc overexpression (26, 27, 28).