SLC12A5 and interstitial lung disease: These findings regarding the role of KCC2 on baseline chloride, chloride elevations during ILD activity, Cl– extrusion rates and ILD activity resolve conflicting reports in the literature, provide a coherent understanding of the role KCC2 activity in chloride homeostasis during ILDs, and support the feasibility of developing KCC2 modulators into sorely-needed anticonvulsant medications.