Moreover, among the three major proteins of the necrosome complex, p-RIPK protein expression was specifically increased by treatment with SM/z-VAD and ABT-263 in YARS-positive breast cancer cells; the expression of this protein increased further upon additional treatment with H2O2 in the MDA-MB-231 cell line (Supplementary Fig. S6). Here, YARS1 is linked to breast carcinoma.