Numbers of events experienced during follow-up were statistically correlated with age, male sex, white background, tobacco use, prior CV disease, heart failure, diabetes duration, systolic blood pressure, HbA1c, use of beta blockers, blood pressure drugs (other than renin-angiotensin system modulators), antiplatelet drugs, sulfonylureas and insulin, and were inversely related to eGFR, and metformin use. This evidence concerns the gene REN and heart failure.