PRKN and Parkinson disease: Various genes are involved in the development of PD and astrocyte biology [95], including PARK7 (encoding DJ-1), SNCA (encoding α-synuclein), PARK2 (encoding Parkin), PLA2G6 (encoding Ca2+-independent phospholipase A2), ATP13A2 (encoding lysosomal type 5 ATPase, ATP13A2), LRRK2 (encoding leucine-rich repeat kinase 2, LRRK2), GBA (encoding β-glucocerebrosidase, GCase), and PINK1 (encoding PTEN-induced putative kinase 1, PINK1) genes [95].